PE-22-28 10mg research vial
PE-22-28 is a lab-made 7 amino acid peptide cut down from spadin; one 10mg vial costs 2,300,000 VND ($90 USD). The three PE-22-28 papers below each open on PubMed, and the price on this page was checked on 11 October 2026.
What is PE-22-28?
Spadin is a 17 amino acid piece of a protein called sortilin. It blocks TREK-1, a potassium channel in nerve cells.
PE-22-28 is a shorter version, made to block that channel more strongly.
Good to know
PE-22-28 was made from spadin as a shorter peptide aimed at the same target, TREK-1. Same target, shorter peptide, one team.
PE-22-28 and spadin in mouse studies
- Animal study, 2010. The first spadin paper ran 5 standard behavior tests in mice, tests used to screen for antidepressant-like activity.
- Animal study, 2017. Researchers made PE-22-28 from spadin. Then they measured how strongly it blocked TREK-1, how long it lasted in the body, and how mice behaved in the screening tests.
- Review, 2019. A review of spadin and its short versions in mouse tests, including how quickly spadin breaks down.
A small set of cell and mouse studies from one team in Valbonne, France, and our search found no human study. Mouse tests like these are screening models, not proof of an effect in people.
How to read this
Two things set the limits here. The 2010 and 2017 studies come from one team in Valbonne, France, and the research our search found comes from that team. And mouse behavior tests, like the forced swim test, are screening tools used to spot compounds worth studying further. A screening test in mice is a reason to look closer, not a result in people.
The PE-22-28 paper trail
The 2010 and 2017 papers come from one lab, the Institute of Molecular and Cellular Pharmacology (CNRS) in Valbonne, France. The 2010 paper, in PLoS Biology, first described spadin and ran mice through five standard behavior tests. The 2017 paper, in Frontiers in Pharmacology, is the one that made PE-22-28. The 2019 review adds a practical point about the parent: spadin breaks down within hours. Every PE-22-28 study in our search traces back to that one French team, so no outside lab has checked the work yet.
Sources: PubMed record 20405001 (animal study, 2010); PubMed record 28955242 (animal study, 2017); PubMed record 30291907 (review, 2019).
How much does PE-22-28 cost per pack?
| Pack | Price | Per vial | Per mg |
|---|---|---|---|
| 1 vial | 2,300,000 VND ($90 USD) | 2,300,000 VND ($90 USD) | 230,000 VND ($9 USD) |
| 3 vials | 5,589,000 VND ($218.70 USD) | 1,863,000 VND ($72.90 USD) | 186,300 VND ($7.29 USD) |
| 5 vials | 8,280,000 VND ($324 USD) | 1,656,000 VND ($64.80 USD) | 165,600 VND ($6.48 USD) |
| 10 vials | 13,800,000 VND ($540 USD) | 1,380,000 VND ($54 USD) | 138,000 VND ($5.40 USD) |
Questions about PE-22-28
What has research on PE-22-28 looked at?
Mood-related behavior tests in mice, from one French team. Our search found no human study.
What is spadin?
Spadin is a 17 amino acid piece cut from a protein called sortilin. PE-22-28 is a shorter version, made from it by the same French team.
What is TREK-1?
A potassium channel: a pore in the wall of nerve cells that potassium passes through. Spadin blocks it, and PE-22-28 was made as a shorter version of spadin.
How many papers name PE-22-28?
One. Searching PubMed on 18 October 2026, we found a single record that uses the name PE-22-28: the 2017 paper listed here. The rest of the research is on spadin, its longer parent.
By Peptides Ho Chi Minh, 11 October 2026